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Inside our study, we were being in the position to noticeably escalate the dose of CX-5461 outside of that reached in the primary-in-human examine in sufferers with hematologic cancers. The RP2D of 475 mg/m2 on days one, 8, and fifteen of a four-week cycle, was dependant on phototoxicity, which happened Irrespective of rigorous UV light avoidance